Where Is Cholesterol Produced In The Body

Where Is Cholesterol Produced In The Body You Are Asking.

Before learning about where is cholesterol produced in the body, it is important to know what is cholesterol.

Cholesterol is a waxy, fat-like substance that can be found in body cells of human beings and animals. Cholesterol is sometimes referred to as "good" cholesterol and "bad" cholesterol. In fact, these descriptions refer to the substances called lipoproteins that carry cholesterol throughout the body in the bloodstream. Lipoproteins are a combination of varying amounts of fats and proteins.

Cholesterol is needed in the membranes of our cells in order for them to function normally,
So now, if you ask yourself where is cholesterol produced in the body, here are some interesting answers to your question.

Cholesterol in the body comes from two major sources: one of major source of cholesterol is the one produced by the body, the majority of which comes from the liver. The other source comes from foods of animal origin, such as meat, milk, and eggs that we have in our diet.

We can also say that cholesterol is either synthesized in the endoplasmic reticulum (ER) or comes from our diet, in which case it is transported by the bloodstream in low-density or high-density lipoproteins. Low-density lipoproteins are taken into the cell by LDL receptor-mediated endocystosis in clathrin-coated pits, and then hydrolysed in lysosomes.

The basic structure and composition of the ER membrane is similar to the plasma membrane ,
Cholesterol is synthesized in almost every cells, and, as mentionned earlier, a large quantity of it can be absorbed from what we eat in our diet.

The liver produces about 1 gram of cholesterol every day, in bile. Most of the cholesterol in the body is synthesized therein. Cholesterol is more abundant in tissues which either synthesize more, or have more abundant, densely-packed membranes, such as the liver, the brain and spinal cord.

So, to be more specific in your answer to where is cholesterol produced in the body, we can say that cholesterol is primarily synthesized fromCoA through the HMG-CoA reductase pathway in many cells and tissues. About 20-25% of total daily production (about 1 gram a day) occurs in the liver; other sites of high synthesis rates include the the reproductive organs, the intestines and the adrenal glands. For a person of about 68 kilograms (150 pounds), typical total body content is about 35 g, typical daily internal production is about 1 g and typical daily dietary intake is 200-300 mg in the United States and countries with similar patterns in their diets. 92-97% of the cholesterol released into the intestines in bile is reabsorbed in the intestines and recycled through enterohepatic circulation.
 
Now, if you have friends asking you where is cholesterol produced in the body, you wil know what to answer with your new found knowledge.

Congratulations!